By A. Abell

Peptidomimetics have stumbled on large software as bioavailable, and infrequently effective mimetics of traditional peptides. They shape the root of vital sessions of enzyme inhibitors, they act as receptor agonists and antagonists, and so they have even been used to imitate DNA constitution. contemporary advances within the use of solid-phase natural synthesis have lead the way for the training of libraries of those constructions to permit the fast optimization of theri organic houses and accordingly healing power. we're additionally commencing to achieve a better knowing of the structural beneficial properties of this type of compounds that impact their skill to permeate membranes, and their fee of clearance and metabolism. This quantity brings jointly lots of those serious concerns by means of highlighting contemporary advances in a couple of center peptidomimetic-based examine.

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4. Hruby, V. J. In The Practice of Medicinal Chemistry; Wermuth, C. ; Academic Press: London, 1996, p. 135. 5. Ostresh, J. ; Husar, G. ; Blondelle, S. ; Weber, P. ; Houghton, R. A. Proc. Natl. Acad. Sci. USA 1994, 91, 11138. 6. Rose, G. ; Giersach, L. ; Smith, J. A. Adv. Protein Chem. 1985, 37, 1. 7. (a) Dyson, H. L; Cross, K. L; Houghten, R. ; Wilson, I. ; Wright, P. ; Lerner, R. A. Nature 1985, 318, 480. ; Montelione, G. ; Scheraga, H. A. J. Am. Chem. Soc. 1984, 106, 7959. (c) Friedinger, R. ; Veber, D.

An example of the synthetic methodology developed is described (Scheme 37). Coupling of 4-bromobutyric acid to the resin-bound amido amine 143 yielded the bromide 144. Displacement of the halide with various aromatic nucleophiles (thiophenols, anilines, aminopyridines) affords the products 145, prior to cleavage from the solid-support. After iterative modifications of the aryl ether moiety, linker moiety, carboxy terminus, and 2-aminoindane moiety, the 3,4-dichlorophenyl derivatives 146a-c were identified with improved potency in the CaPMI inhibition kinetic studies.

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