By Michael P. Murtaugh PhD, Nancy A. Monteiro-Riviere PhD, Linda Panepinto BS (auth.), Mike E. Tumbleson, Lawrence B. Schook (eds.)
Similarities in constitution and serve as among pigs and people contain dimension, feeding styles, digestive body structure, nutritional behavior, kidney constitution and serve as, pulmo nary vascular mattress constitution, coronary artery distribution, propensity to weight problems, breathing charges, tidal volumes and social behaviors. because the pig is an omnivore, it presents an adaptable version to judge continual and acute exposures to xenobiotics reminiscent of alcohoL caffeine, tobacco, meals ingredients and environmental toxins. Swine were used effectively as types to guage alcoholism, diabetes, absorption, digestion, overall paren teral nutrients, organ transplantation, atherosclerosis, workout, high blood pressure. hemorrhagic hypotension, cancer, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal therapeutic and septic surprise. A serious and aggravating scarcity of organs and tissues for transplantation in sufferers with critical organ failure has inspired the glory of inter species or xenotransplan tation. In constructing courses towards this finish, the pig quite often is considered because the hottest donor due to its measurement, body structure and availability. The pig harbors particularly few illnesses that may be transmitted inadvertently to human sufferers. the power to genetically regulate swine to ameliorate the implications of the human immune reaction deals yet another major virtue. one other very important attention for an animal version is that simple biologic again flooring details be on hand for investigators to layout destiny potential studies.
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Extra info for Advances in Swine in Biomedical Research: Volume 2
Invest. Dermatol. 102:796-798. 456 N. A. Monteiro-Riviere and J. Riviere 58. , 1993, Development and characterization of an isolated and perfused tumor and skin preparation for evaluation of drug disposition, Cancer. Res. 53:101-105. 59. , 1991, The effects of sodium hydroxide and hydrochloric acid on isolated perfused skin, In Vitro Taxieal. 4:207-215. 60. , 1992, Cutaneous toxicity and absorption of paraquat in porcine skin, Taxieal. Appl. Pharmacal. 115:89-97. 61. , in: Prac. Ninth Med. Defense Siasci.
A. Monteiro-Riviere and J. Riviere were not caused by ischemic changes or technical problems associated with the IPPSF. SBC in vitro and in situ appeared morphologically similar to those detected in in vivo exposures but were present in lower numbers. Mean SBC numbers were directly proportional to dose and increased in numbers at 24 compared to 8 hr. When these numbers were corrected for control values, in vivo and in vitro responses were identical. SBC found in pig epidermis were described as histologically76 and ultrastructurally77 similar to those in UVB exposed human skin.
This dose also showed a relative decrease in GF. VR of 630 mJ/cm2 in vitro dosed flaps was high~r than other doses. The profile increased at 4 hr and was higher than 315, 1260 or control flaps. High concentrations ofPGE 2 have been reported to increase vascular permeability, which may increase flap edema and YR. The IPPSF qualitatively and quantitatively responds in a manner consistent with current human and animal model data. Because of its anatomical complexity, all aspects of the pathogenesis of UVB phototoxicity may be investigated humanely in a single preparation.