By Jean D. Sipe
A first-stop reference on proteins linked to amyloidosis. This e-book is the 1st to offer a scientific evaluation of all identified fibril-forming proteins, together with their biochemical features and pathophysiology. It considers the clinically famous amyloid proteins which are recognized to be linked to the amyloid protein folding issues, facing their universal structural and thermodynamic positive aspects that bring about amyloid fibril formation and sickness. Emphasis is at the thermodynamics of protein folding, the constitution and physiologic results of universal oligomeric and subfibrillar intermediates and the impact of the extracellular matrix and mobile trafficking and metabolism at the genesis and catabolism of beta pleated sheet proteins. The chapters on particular amyloid proteins all persist with a standard constitution, permitting easy accessibility to the specified biochemical and scientific info, making this a useful instrument for clinicians and researchers alike.
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Extra info for Amyloid Proteins: The Beta Sheet Conformation and Disease
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