By Jean D. Sipe

A first-stop reference on proteins linked to amyloidosis. This e-book is the 1st to offer a scientific evaluation of all identified fibril-forming proteins, together with their biochemical features and pathophysiology. It considers the clinically famous amyloid proteins which are recognized to be linked to the amyloid protein folding issues, facing their universal structural and thermodynamic positive aspects that bring about amyloid fibril formation and sickness. Emphasis is at the thermodynamics of protein folding, the constitution and physiologic results of universal oligomeric and subfibrillar intermediates and the impact of the extracellular matrix and mobile trafficking and metabolism at the genesis and catabolism of beta pleated sheet proteins. The chapters on particular amyloid proteins all persist with a standard constitution, permitting easy accessibility to the specified biochemical and scientific info, making this a useful instrument for clinicians and researchers alike.

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Extra info for Amyloid Proteins: The Beta Sheet Conformation and Disease

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D. Termine. bpleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils. J Histochem Cytochem 1974, 22, 1141–1158. Glenner, G. , W. Terry, M. Harada, C. Isersky and D. Page. Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analysis. Science 1971, 172, 1150–1151. Benditt, E. P. Amyloid protein AA and its precursor, the acute phase protein(s) apoSAA: a perspective. In Amyloidosis, J. Marrink and M. H. van Rijswijk (eds). Martinus Nijhoff, Dordrecht, 1986, pp.

Am J Pathol 1971, 65, 231–252. , P. Westermark and J. B. Natvig. Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid. J Exp Med 1976, 143, 993–998. Benditt, E. P. and N. Eriksen. Chemical similarity among amyloid substances associated with long standing inflammation. Lab Invest 1962, 26, 615–625. Benditt, E. P. and N. Eriksen. Amyloid, III. A protein related to the subunit structure of human amyloid fibrils. Proc Natl Acad Sci USA 1966, 55, 308–316. Benditt, E. , N.

Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and nondiabetic individuals. Am J Pathol 1961, 38, 49–59. Pearse, A. G. , S. W. B. Ewen and J. M. Polak. The genesis of apudamyloid in endocrine polypeptide tumours: histo- 158 159 160 161 162 163 164 165 166 167 168 chemical distinction from immunamyloid. Virchows Arch B Zellpathol 1972, 10, 93–107. Westermark, P. Amyloid of human islets of Langerhans. I. Isolation and some characteristics. Acta Pathol Microbiol Scand C 1975, 83, 439–446.

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