By Richard A. Kahn
For the 1st time specialists within the region of signalling study with a spotlight at the ARF kin have contributed to the creation of a identify dedicated to ARF biology. A complete phylogenetic research of the ARF kinfolk, tables of the ARF GEFs and ARF GAPs, and greater than a dozen chapters describing them intimately are supplied. The influence of the ARF proteins on greatly diversified features of mobile biology and cellphone signalling may be basically visible from the actions defined; together with membrane site visitors, lipid metabolism, receptor desensitization, mouse improvement, microtubule dynamics, and bacterial pathogenesis. an individual attracted to figuring out the complexities of phone signalling and the combination of signalling networks will take advantage of this quantity.
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Extra info for ARF Family GTPases (Proteins and Cell Regulation)
259, 6228-6234. Kahn, R. , and Gilman, A. G. (1986). The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. J. Biol. , 261, 7906-7911. Kahn, R. , Kern, F. , Gelmann, E. , and Rulka, C. (1991). Human ADPribosylation factors. A functionally conserved family of GTP-binding proteins. J. Biol. , 266, 2606-2614. , and Nakano, A. (1995). Purification and assay of yeast Sar1p. , 257, 41-49. , McLaren, M. , and Inana, G. (2003). Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain.
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LOGSDON AND KAHN NOMENCLATURE ISSUES IN THE ARF/ARL FAMILY Because this chapter focuses on the evolutionary relationships between highly conserved proteins, we have adopted a simpler system of naming the Arf family members in the different species that emphasizes the family relationships. Any time you deal with gene families in multiple species today you are likely to encounter issues regarding how proteins and genes are named or referred to by researchers and the databases. And while it is important to maintain the evidence of priority in discovery that may result from deposition into databases, it does not make sense to continue using names that are misleading or incorrect.