By Clint E. Carter, Brian M. Wickwire (auth.), Thomas C. Cheng (eds.)

The learn of parasites and their interactions with hosts maintains to symbolize a not easy region of contemporary biology. the supply of recent innovations and instrumentation, coupled with the advance of bold new hypotheses and ideas, has prepared the ground for the dramatic evolution of parasitology from a static descriptive activity to a dynamic one according to biochemistry, immunology, molecular biology, and smooth phone biology. reports of this nature evidently fall in the area of pathobiology. for this reason, while the contributions incorporated during this quantity of Comparative PathobioZogy have been provided to this sequence. after severe overview, we welcomed the chance to cause them to on hand to the clinical neighborhood. The contributions incorporated herein signify shows brought sooner than enthusiastic audiences at 3 varied symposia, all held in 1983. the 1st, entitled "Some points of contemporary Parasitology", was once geared up through Dr. Gary E. Rodrick of the college of South Florida and myself on behalf of the yank Society of Zoologists. The chapters by way of C. E. Carter and B. M. Wickwire. B. J. Bogitsh, and W. M. Kemp have been initially offered at that symposium. the second one symposium. prepared by means of Dr. G. Balouet of the Faculte de Medecine, Brest, France, and myself on behalf,of the Society for Invertebrate Pathology, was once entitled "Cellular Reactions in Invertebrates." The chapters by way of G. Balouet and M. Poder and M. Brehelin have been initially awarded at this symposium.

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J. Exp. , 148, 46-57. Smithers, S. R. and Terry, R. J. (1967). Resistance to experimental infection with Schistosoma mansoni in rhesus monkeys induced by the transfer of adult worms. Trans. Roy. Soc. Trop. Med. , 61, 517-533. Smithers, S. , Terry, R. , and Hockley, D. J. (1969). Host antigens in schistosomiasis. ~oc. Roy. Soc. Lond. ), 171, 483-494. Sogandares-Berna1, F. (1976). Immunoglobulins attached to and in the tegument of adult Schistosoma mansoni Sambon 1907, from first infection of CF1 mice.

34 I. INTRODUCTION In contemplating how best to present this topic I was faced with two approaches. One was to catalogue all the parasites about which we know something of immune escape and list the mechanisms associated with each. The other approach was to choose one parasite and to detail our knowledge of escape mechanisms in a more exhaustive way. I have elected to pursue the second approach so that the subject may be examined in depth and the complexities of the mechanisms more easily discerned.

C. (1971). Ultrastructure of the esophageal region in Amep. J. Tpop. , 20, 552-568. Schistosoma mansoni. Dresden, M. H. and Dee1der, A. M. (1979). " Exp. PapasitoZ. 48, 190-197. Ehrenreich, B. A. and Cohn, Z. A. (1969). The fate of pep tides pinocytosed by macrophages in vitpo. J. Exp. , 129, 227243. Erasmus, D. A. (1977). The host-parasite interface of trematodes. Adv. , 15, 201-242. Ernst, S. C. (1975). Biochemical and cytochemical studies of digestive-absorptive functions of esophagus, cecum, and tegument in Schistosoma mansoni: acid phosphatase and tracer studies.

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