By Geoffrey B. Cox
The improvement of chiral liquid chromatography, facilitating the easy separation of enantiomers, used to be an important boost in chromatography, resulting in common software in analytical chemistry. software in preparative chromatography has been much less fast, yet with the improvement of unmarried enantiomer prescribed drugs its use is more and more universal in chemical synthesis at laboratory, pilot plant or even complete creation scale.
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12 Separation of guaiphenesin enantiomers on CHIRALPAK OD, 50 × 5 cm, flow rates: 50, 100, 200 and 400 mL/min. Injected quantity: 11 g. 2 Production rate This is the rate of production of the desired product, again usually in terms of mass per unit time. This takes into account the recovery yield losses and also the purity of the final product. Both the above parameters are dependent upon the details of the preparative separation. Each is clearly dependent upon the column diameter and the flow rate.
If we assume for the moment that the performance of columns packed with particles of diameter between 5 and 100 m can be described by the Knox equation, then we can calculate the length and flow rate for such columns as a function of the particle size. 4 assume a column diameter of 5 cm and methanol as solvent. In this example, the production rate is related to the flow rate through the column; as all columns have identical efficiency, the separation is achieved within a given number of column volumes of solvent – the faster the solvent flow, the greater the number of injections that can be made per unit time.
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