By Odd Nygård, Peter Westermann (auth.), Abraham K. Abraham, Thor S. Eikhom, Ian F. Pryme (eds.)
During the prior decade now we have witnessed numerous significant dis coveries within the sector of protein synthesis and post-translational amendment of protein molecules. during this quantity, a number of the lat est study advancements in those fields are pronounced via the dis tinguished overseas staff of scientists who awarded their state of the art effects on the thirteenth Linderstr0m-Lang convention held at God0Ysund, Norway, June 14-18, 1983. We believe that the presentation right here of so large a number of articles on either the molecular and the mobile features of protein synthesis could be of substantial price to many scientists operating within the zone who have been not able to wait, in addition to to many that are lively in comparable parts. as well as the learn papers, the contents of the six clinical classes held through the convention were summarized by way of the respective consultation chairmen. those person summaries supply insightful syntheses of the entire contemporary development in each one box, establish which present difficulties stay of targeted inter est, and recommend what the long run may well carry within the a number of components of protein synthesis learn lined. even though this quantity evidently can't supply an entire survey of all very important ongoing examine at the molecular and mobile biology of translational and post-translational occasions, we're confi dent that it'll facilitate a far better knowing of many im portant modern difficulties in study on protein synthesis, together with phone differentiation, translational accuracy, protein modifi cation, intracellular shipping, and membrane turnover.
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Extra info for Protein Synthesis: Translational and Post-Translational Events
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This finding plus a curiousity as to th;-protein responsible for the ATP requirement prompted an attempt to establish what should be the reciprocal assay to ATPdependent mRNA binding, namely RNA-dependent ATP hydrolysis. Some of our results using this assay are indicated in Table III. From this table several observations can be made. First, although the value for eIF-4B is not zero, it would appear that eIF-4A and eIF-4F are responsible for most of the ATP hydrolysis activity. This is apparent in experiment A using globin mRNA to stimulate ATP hydrolysis from lines 1, 3, and 6.