By J. Kiefer (auth.), Prof. Dr. Jürgen Kiefer (eds.)

Radiation is the single agent between all environmental components which can harm organic platforms that's not basically simply quantifiable yet is usually measured with unsurpassed answer. Its basic results on atoms and molecules are good understood, and the secondary strategies could be by means of subtle experimental innovations. The quantum nature of interactions and the significance of stochastic diversifications demand an actual mathematical description. This job is under no circumstances easy, and provides a problem either to the experimentalist and to the theoretician. it really is was hoping mostly appropriate formalism may also help to quantify radiation responses, either in radiation safeguard and radiation treatment, and give the chance to maneuver from a basically empirical process with all its fallacies to actual understanding.

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Additional resources for Quantitative Mathematical Models in Radiation Biology: Proceedings of the Symposium at Schloss Rauisch-Holzhausen, FRG, July 1987

Example text

If the experimentalist hopes to understand the basic mechanisms of the responses of cells to radiation, he must recognize and describe completely the set of properties possessed by each kind of effect independently of the others; and then search for interactions among these after isolation and description of each. The "total response" of the cell (even when measured as a single end point such as cell death) is some kind of sum of the individual kinds of radiationinduced effects, and any theory or model that purports to represent cell response must be constructed to demonstrate that clearly and unambiguously.

Kill) ---------------------------(6) where beta is from equation (5) with the proper values of CT and t substituted. Neither solid line is near its unperturbed value, neither is a straight-line exponential, one is convex down and the other up, and each fits its set of points very well. Another example is presented in Figure 4. Here cyclotron 2 MeV neutrons were delivered at 1000 radslmin at 20°C. At 600 krad the irradiation time was 10 hours, and even though room temperature was 20°C, the time-temperature factor was large enough to cause departure from expected first order behavior because of significant thermal annealment of radicals measured by kill.

H. S. Gordeev, H. de Waard, and F. Saris, The Production of Continuous Electron Spectra in Collisions of Heavy Ions and Atoms. B: Direct Coupling with Continuum. J. Phys. B14 (1981) 527 23 M. Inokuti, Radiation Physics as a Basis of Radiation Chemistry and Biology, Applied Atomic Collision Physics, Vol. , 1983 24 R. C. Sharma, and M. Homayoonfar, The Structure of Particle Tracks, in: Topics in Radiation Dosimetry, Suppl. 1, p. 317, F. H. Y. G. H. V. S. W. A. 5 MeV/amu, Phys. Rev. A30 (1984) 722 26 B.

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