By Peter Barnes (auth.), Primarius Dr. Hartmut Zwick (eds.)
The Austrian Pneumological Society held its 33th Workshop on "Clinical breathing body structure" at Graz, November 1 st -3rd, 1990. Bronchial hyperresponsiveness has been recognized approximately so long as bronchial asthma bronchia Ie itself. over the last 20 years whereas exploring the inflammatory nature of bronchial asthma bronchiale we've got discovered much approximately measuring and enhancing this phenomenon. end result of the useful relevance and due to the excessive competence of the authors we are hoping that the lectures and discussions we had at Graz will tell and luxuriate in the reader. i need to specific my deep gratitude to all of the authors for supplying us with the manuscripts and graphs. eventually i'm particularly thankful to Mrs. H. Weber for her secreterial paintings and to Mrs. magazine. A. Lahrmann-Ramharter for correcting the written model of the speeches and getting ready a manuscript that used to be prepared for the click. Prim. Dr. Hartmut Zwick Contents Barnes P. : mobile and Biochemical elements of Airway Hyperresponsiveness. . . . . . . . . . 1 Hargreave F. E. : Airway Hyperresponsiveness and bronchial asthma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Ingram R. H. : Physiologic Correlates of elevated Airway Responsiveness . . . . . . . . . . . . . . . . 36 okay errebijn okay F. : Bronchial Provocation trying out in kids -Methods and medical Relevance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . forty six Tattersfield A. E. : Bronchial Provocation trying out in Adults -Is There scientific Relevance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . sixty four Kummer F. : ideas and techniques in bronchial asthma remedy. . . . . . . . . . . . . . . . . . . . . . . . . .
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Extra info for Bronchial Hyperresponsiveness
Example text
Secondly the position and maximal response plateau of the dose-response-curve can be used for instance in patients suspicious of over- and underdiagnosis, more importantly in patients who consider themselves cured. That is often the case in adolescence. Remission ("cure") is defined as a lack of symptoms, normal airway caliber, litte increase in FEV1 or peak expiratory flow (PEF) after bronchodilator and bronchial responsiveness within the normal range. But first we have to answer the question: is bronchial hyperresponsiveness a sensitive marker of pathology, of disease activity?
Both symptoms and the degree of responsiveness vary from one time to another. It is therefore not surprising that these could have occurred in the past but are not present at the time of measurement of responsiveness. This would be one cause of symptoms with normal responsiveness. Some people do not recognize variable airway obstruction. This has been observed in a group of children who denied symptoms of asthma but who had Airway Hyperresponsiveness and Asthma 25 methacholine hyperresponsiveness.
E. the more they constricted, following a DI at baseline, the more responsive they were to a subsequent challenge with methacholine (4). _ m :;:, .... 0 :;:,- • •• • •• • • • • '0 > 0 0 2 Log PO 35 SGAW MCH Fig. e. the more responsive individuals reverse their obstruction less with a 01 than ones less responsive. Redrawn from reference 5. Ingram R. : 40 In another group of mild asthmatics, all increased their VHR with methacholine induced obstruction (fig. 3). However, the VHR during induced obstruction was less in the more responsive subjects.