By P. Giannakopoulos, P.R. Hof, J. Bogousslavsky
This book summarizes the latest advances in neurobiology, diagnostic methods and therapeutics of the key dementing health problems comparable to Alzheimer’s disorder, frontotemporal dementia, Lewy physique affliction, and vascular dementia. In a succinct, functional and finished demeanour, it offers an up-to-date view of the issues more likely to be encountered in an everyday perform. every one part is concentrated on an incredible type of dementia and is prepared following a similar scheme reviewing the pathophysiology of the ailment, its diagnostic demanding situations, its attribute neuroimaging gains, healing interventions and sufferer administration matters. warding off an overspecialized method, the ebook bridges the distance among scientific perform, complex imaging, fresh therapeutics and simple sciences. therefore, it serves as an exceptional advisor for psychological overall healthiness execs operating within the box of dementia in addition to basic care physicians and scholars.
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Additional info for Dementia in Clinical Practice (Frontiers of Neurology and Neuroscience)
Example text
The density of serotonin receptors has been shown to increase in MCI as opposed to AD patients (upregulation), suggesting that compensatory mechanisms may exist at early stages of the degenerative process [30]. In conclusion, research efforts are needed to identify biomarkers with high specificity for each lesion type. With such biomarkers, the concept of MCI syndrome will be more restricted, since an accurate demonstration of the lesions would definitely posit the diagnosis of dementia. References 1 Petersen RC, Smith GE, Waring SC, Ivnik RJ, Kokmen E, Tangelos EG: Aging, memory, and mild cognitive impairment.
In association with clinical information, the topographic localization of the hypometabolism will help to precise the type of dementia. Functional brain activation studies using functional MRI and PET are not used for clinical purpose, but they allow to determine the differences between control and pathological states and thus to characterize the functional abnormalities specific to the disease. Finally, the use of biomarkers of the neuropathological lesions constitutes the most promising tool to accurately diagCopyright © 2009 S.
But, with the evolution of the disease, there is a progressive decrease of glucose metabolism as shown by the negative correlation between age and hippocampus metabolism (fig. 2). On the other side, patients with clear dementia symptoms present cerebral hypometabolism within associative parietal areas, external temporal areas, precuneus, posterior cingulate cortex, the dorsolateral frontal cortex becoming affected with disease evolution [14]. This topography differs from frontotemporal dementia, in which the frontal lobes and anterior temporal lobes are preferentially concerned [15] (fig.