By S. Garagna
Reprint of: Cytogenetic and Genome examine 2004, Vol. one zero five, No. 2-4 the home mouse holds a distinct position between version organisms, representing an integral instrument for plenty of investigators, quite in biomedical examine. Mouse genetics encompasses approximately a hundred years of analysis and culminated within the booklet of the mouse genome series in 2002, from which the assumption for this unique factor arose. the difficulty positive factors 37 peer-reviewed papers supplying a wide-ranging evaluation of all significant facets of mouse genetics, from nuclear move and embryonic improvement to melanoma, from copy to speciation and practical genomics applied sciences. Its target is to give an appropriate software of research for the massive inhabitants of researchers that use the mouse as a version animal. overlaying quite a few themes, this e-book may be an invaluable consultant for scientists operating within the fields of copy, improvement, evolution, melanoma, toxicology, and phone biology in addition to for newcomers coming into the realm of mouse genetics.
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Extra info for Mouse Genetics After The Mouse Genome: Cytogenetic And Genome Research 2004
Sample text
RBP protein was also shown to be synthesized and secreted by rat Sertoli cells in culture (Davis and Ong, 1992). The observation of the uptake of tritiated retinol from retinol-RBP or retinol-RBP-TTR complexes by cultured Sertoli cells led to the hypothesis that serum retinol is chaperoned by RBP and TTR first to the peritubular cells, and finally to the Sertoli cells (reviewed in Eskild and Hansson, 1994; Kim and Akmal, 1996). , 1999) (discussed in section V). Using autoradiography, Rajguru and colleagues (1982) demonstrated that labeled retinol is primarily localized to three cellular sites within the adult rat testis: macrophages of the interstitial tissue, lipid droplets of the Sertoli cells, and in spermatids in association with Golgi saccules.
1997). , 1995). ADH2 has a very limited tissue distribution, being found only in adult liver and possibly human skin (Duester, 2000). Reviews with a particular focus on the mouse SDR family including several microsomal enzymes able to oxidize retinal to reti- naldehyde in vitro may be found in the papers by Duester (2000) and Duester et al. (2003). , 1999a, b). , 1999a, b). , 2002). , 2002). Whether the testes of the mutant strains would exhibit enhanced sensitivity to excess vitamin A or more pronounced response to VAD remains to be determined.
198 38 Cytogenet Genome Res 105:189–202 (2004) Degrading enzymes ATRA is a crucial signaling molecule involved in tissue morphogenesis during embryonic development. The distribution and concentration of ATRA is precisely regulated during embryogenesis by balanced complementary activities of synthesizing (RALDH) and metabolizing (CYP26) enzymes. Three classes of CYP26 have been reported including A1, B1 and B2 (also designated C1). , 1997). ATRA can cause direct and rapid induction of Cyp26a1 due to the presence of a highly conserved 32-bp element containing a canonical, direct repeat-5 type of RARE in the 5) upstream promoter region (reviewed in Ross, 2003).