By Howard M. Fillit MD

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It is a technique that is particularly well suited for clinical trials designed to prevent AD or slow its progression. The Alzheimer's Disease Cooperative Study, a multicenter consortium that performs AD-related clinical trials, is presently conducting a clinical trial with vitamin E and donepezil (Aricept®) in participants with mild cognitive impairment (MCI). The objective of the trial is to determine if either agent is capable of delaying a diagnosis of AD. Mild cognitive impairment participants are randomized to treatment with vitamin E, donepezil, or placebo, and followed longitudinally for 3 years.

4. The three-dimensional (3-D) mapping technique employed at UCLA (Thompson & Toga, 1996; Thompson, Schwartz, & Toga, 1996). 33 34 Early Detection m s/ in de x. ph p The specific aims of the proposal are: (a) to obtain intercenter reliability data on these four techniques using a common shared database of scans obtained on both control and MCI patients; (b) to obtain sensitivity and specificity data on these four assessment techniques across centers in the identification of MCI versus control participants; and the 15 incipient AD participants within the MCI cohort; and (c) using the center-wide normative control data derived from this study, with its data on hippocampal volumetric variability, provide web-based tools to assess future patients with MCI, using the most efficient and clinically useful technique identified in the second specific aim.

8th order AIR, Roger Woods' software package that is freely available on the web) that brings a new participant into the atlas template, the hippocampal surface was brought from the atlas to segment the new participant's native data for volumetric assessment. By jack-knifing each participant tested so that their contour does not make up the average atlas, an estimate of the validity of this assessment was achieved based on their manual outlines. 3), this procedure would require little manual interaction with the data.

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