By Anil K. Nair, Marwan N. Sabbagh
Aging impacts neurological functionality resulting in neurological disease
As society grows older, so do the neurological difficulties linked to getting older. those may be new neurological deficits as a result of the getting older approach itself, or the impression of getting older on already present neurological stipulations. Neurologists will spend expanding quantities of time coping with sufferers with age-related neurological complications.
Geriatric Neurology brings jointly the knowledge of world-leading specialists. they've got crafted a brand new textbook to outline this rising subspecialty from simple technological know-how via scientific evaluate and scientific administration to social features of sufferer care. Geriatric Neurology covers: * The getting older mind in neurology * overview of the geriatric neurology sufferer * Neurological stipulations within the aged * Therapeutics for the geriatric neurology sufferer * administration concerns past therapeutics
Comprehensive in scope yet with sensible concentration for powerful sufferer care, Geriatric Neurology presents top-of-class information for the administration of aged sufferers with neurological issues.
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Additional resources for Geriatric Neurology
Additionally, both age- and disease-associated (with AD) reductions in the autophagy regulatory protein beclin 1 have been found in patient brain samples (Cherra and Chu, 2008), while treatments that promote autophagy The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty-First Century have been shown to reduce levels of pathological proteins in several in vivo and in vitro models of neurodegeneration. Rapamycin, lithium, and several polyphenols have been shown to enhance degradation and also possibly reduce synthesis of proteins that may contribute to toxic oligomer formation, as well as larger extracellular aggregates of toxic protein seen in several neurodegenerative diseases.
Experimental animals genetically defective in autophagy develop neurodegeneration accompanied by ubiquitinated protein aggregates, demonstrating that basic autophagy function is essential for long-term neuronal health. Additionally, both age- and disease-associated (with AD) reductions in the autophagy regulatory protein beclin 1 have been found in patient brain samples (Cherra and Chu, 2008), while treatments that promote autophagy The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty-First Century have been shown to reduce levels of pathological proteins in several in vivo and in vitro models of neurodegeneration.
Reproduced with permission from US Administration on Aging. The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty-First Century Low P:C diet Levels of glucose AMPK activity Levels of glucose TOR activity Levels of amino acids High P:C diet Levels of amino acids Leptin; insulin/IGF; etc. 4 A schematic summarizing the hypothesis for how diet balance might affect lifespan via the TOR and AMPK signaling pathways. Source: Simpson and Raubenheimer (2009). Reproduced with permission from US Administration on Aging.