By P. Michael Conn

The Handbook of types for Human getting older is designed because the simply accomplished paintings on hand that covers the range of getting older types at present to be had. for every animal version, it offers key facets of biology, food, components affecting lifestyles span, equipment of age decision, use in examine, and disadvantages/advantes of use. Chapters on comparative versions take a vast sweep of age-related illnesses, from Alzheimer's to joint affliction, cataracts, melanoma, and weight problems. additionally, there's an ancient assessment and dialogue of version availability, key tools, and moral issues.

  • Utilizes a multidisciplinary approach
  • Shows tips and ways no longer on hand in basic publications
  • First quantity of its sort to mix either equipment of analysis for human getting older and animal models
  • Over 2 hundred illustrations

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Extra resources for Handbook of Models for Human Aging

Example text

This synopsis above has a hidden assumption, the assumption that the number of animals in the two comparison groups should be the same. The design is "balanced," in the sense that each group has the same size, and such balanced designs minimize the total number of animals tested. This makes good sense when the cost of each test is the same, but in a typical aging experiment the cost of obtaining and testing an elderly mouse may be a good deal higher than the cost for a young control. 1, for example, the production cost of a 25-month-old mouse, under plausible assumptions, may be 10-fold the cost of a 5-month-old mouse.

Positive correlation between mammalian life span and cellular resistance to stress. Free Radical Biology & Medicine 26, 495-500. , and Bartke A. (2001). Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Hormones & Behavior 39, 277-284. , Astle C M . , Archer J. E. (2001). Maximum life spans in mice are extended by wild strain alleles. Experimental Biology & Medicine (Maywood, NJ), 226, 854-859. S. (1993). Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: Possible basis of variation in longevity and metabolic potential.

Long- and short-Uved breeds of dogs, single gene mutants in mice, diet-induced Ufespan expansion—each produces changes of 50% or less in the pace of aging, functional decUne, and change in mortality risks. Evolutionary selective pressures, working on a longer time scheme, can of course do much better. Maximum lifespan within rodents varies from about 4 years in mice to about 30 years in some porcupines and beavers (omitting the naked mole rat on the grounds of poikilothermy). Within the mammals, maximum lifespan seems Ukely to exceed 200 years in bowhead whales, and species with maximal longevity over 50 years are found within several orders and many genera.

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