By Hiroshi Nagasawa (auth.), Benjamin S. Leung Ph.D. (eds.)

The idea that hormones effect tumor progress originated in 1889 with the thought of Albert Schinzinger who instructed that breast melanoma is expounded to the ovaries. numerous years later, Sir George Beatson saw that remission of disseminated breast melanoma should be completed in premenopausal sufferers by way of acting bilateral oophorectomy. a result of contri­ butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal cures were everyday for the therapy of complicated breast cancers for a number of a long time. version structures to review the results of hormones on development and regression of breast tumors were on hand for a few years; even though, the complexities of the hormonal atmosphere have rendered in vivo experiences tricky in guy and experimental animals. lately, the provision of long term cultures of breast melanoma cells has encouraged many investigators to exploit those telephone traces to solve the mechanisms of hormone motion. as a result severe variety and complexity of advances concerning the endocrinology of the breast and breast cancers, a multi-authored evaluate used to be deemed priceless. it's been pleasing to obtain contributions from many famous students. In quantity I of this monograph, the impression of steroid hormones and their antagonists upon common and neoplastic tissues of the mammary gland are awarded. In quantity II, the results of peptide and different hormones are reviewed.

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Pituitary prolactin and growth hormone levels during different reproductive states in mice with a high and a low lactational performance. Horm Behav 2: 73-82, 1971. 65. Yanai R, Nagasawa H. Inhibition of mammary tumorigenesis by ergot alkaloids and promotion of maromary tumorlgenesis by pituitary grafts in adreno-ovariectomized mice. J Natl Cancer Inst 48: 715-719, 1972. 66. Yanai R, Nagasawa H. Enhancement by human placental lactogen of mammary hyperplastic nodules in ovariectomized mlce. Cancer Res 33: 1642-1644, 1973.

Development and growth of pregnancydependent and -independent mammary tumors in GR/A strain of mice and their lnterrelationship. Gann 69: 25-30, 1978. 69. Yang J, Enami J, Nandi S. Regulation of mammary tumor virus production by prolactin in BALB/cfC3H mouse mammary epithelial cells in vitro. Cancer Res 37: 36443647, 1977. 24 70. Yokoro K, Nakano M, Ito A, Nagao K, Kodama Y, Hamada K. Role of prolactin in rat mammary carcinogenesis: Detection of carcinogenicity of low-dose carcinogens and of persisting dormant cancer cell.

8 A o C B 0 CONTROL ..... ovx ! 1 >- '" a: -.... 1 & r 1 a: w ::; "'OJ z a: 0 ::; l I I 1 I 1 i:? O+---~--~----r-~ o 4 4 0 0 WEEKS OF OBSERVATION Fig .. 4. Effect of ovariectomy (OVX) on the number of NMUinduced mammary tumors per rat in the first (A), second (B) and third (C) 4-week periods of observations. The variations in tumor size per rat is shown in Fig. 5, where a somewhat similar pattern is observed. During the three periods of observation, there was a considerable increase in the average tumor area per rat in the control groups while OVX resulted in a stabilization or a regression of the size of the tumors.

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