By H. F. DeLuca (auth.), H. Bickel, J. Stern (eds.)
Read Online or Download Inborn Errors of Calcium and Bone Metabolism: Monograph based upon Proceedings of the Twelfth Symposium of the Society for the Study of Inborn Errors of Metabolism PDF
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Extra resources for Inborn Errors of Calcium and Bone Metabolism: Monograph based upon Proceedings of the Twelfth Symposium of the Society for the Study of Inborn Errors of Metabolism
Example text
B. (1073). Vitamin D and intestinal transport of calcium: effects of prednisolone. Endocrinology, 93, 202 LUMB, G. , MAWER, E. B. and STANBURY, S. W. (1971). The apparent vitamin D resistance of chronic renal failure: a study of the physiology of vitamin D in man. Am. J. , 50, 421 MAWER, E. , HILL, L. , LUMB, G. , TAYLOR, C. M. and STANBURY, S. W. (1975). Parathyroid function and vitamin D metabolism in man. Clin. Sci. Mol. , 48, 349 MAWER, E. , BACKHOUSE, J" TAYLOR, C. , LUMB, G. A. and STANBURY, S.
8). This phenomenon-a net absorption less than normal at a particular level of intake, associated with a proportionate increase of absorption with increased intake-indicates that there are two components in the intestinal absorption of phosphorus. This was further emphasised by the pattern of absorptive response to treatment with vitamin D. In the original metabolic studies of Stanbury and Lumb (1962), it was shown that the treatment of renal osteodystrophy with effective doses of vitamin D produced equimolar increments in the intestinal net absorption of calcium and phosphorus.
This is, of course, unbridled speculation deliberately intended as provocation! But it may be recalled that in SARCOIDOSIS, in which intestinal hyperabsorption of calcium contributes to the development of hypercalcaemia, there is an apparently high incidence of 'primary' hyperparathyroidism. As first pointed out by Jackson and Dancaster (1959), the intestinal hyperabsorption in sarcoidosis involves phosphorus as well as calcium (Figure 2. 7 ~ -;;,' /0 / IY=xI----"'rn / ~ 400~ A/< ~/ ~ ~ ~ 200 ,,* X/c/o ",-7 / .