By Caroline Ashley, Clare Morlidge
This paintings supplies an advent to all elements of drug use in renal failure."Introduction to Renal Therapeutics" is an advent to all points of drug use in renal failure. masking numerous ailments affecting the kidneys, every one bankruptcy discusses the illness method and remedy. It additionally addresses the function of the pharmacist in sufferer care. Case experiences and questions and solutions are integrated on the finish of every chapter.Written through contributors of the united kingdom Renal Pharmacy crew, this e-book can be of specific curiosity to an individual new to, or making plans a profession in, renal pharmacy. it's going to even be of curiosity to nonspecialists who take care of renal sufferers and to pharmacy scholars, and to any physician with an curiosity in renal medication.
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Extra resources for Introduction to Renal Therapeutics
KDOQI Clinical Practice Guidelines for Chronic Kidney Disease: Executive Summary. New York: National Kidney Foundation, 2002. References 5. Department of Health. The National Service Framework for Renal Services. Part Two: Chronic Kidney Disease, Acute Renal Failure and End of Life Care. London: Department of Health, February 2005. 6. Kuan Y, Hossain M, Surman J et al. GFR prediction using the MDRD and Cockroft and Gault equations in patients with end-stage renal disease. Nephrol Dial Transplant 2005; 20: 2394–2401 19 7.
6 Drug-induced acute renal disease Drug-induced renal failure is well recognised, but the frequency with which it occurs with particular drugs is unknown. It is, however, important to be aware of the types of drug that can induce renal failure because there may be a specific antidote or, if suspected and acted on early, the failure may be reversible. Despite a large blood supply, the kidneys are always in a state of incipient hypoxia because of their high metabolic activity, and any condition that causes the kidney to be underperfused may be associated with an acute deterioration in renal function.
In recommending drug dosing it is usually the CrCl that has been used not the eGFR in the summary of product characteristics. Estimated GFR values are increasingly being reported directly from clinical biochemistry laboratories in place of serum creatinine. Limitations of the Modified Diet in Renal Disease equation in calculating eGFR The MDRD formula for estimating GFR should not be used in all situations. 6,7 MDRD has not so far been validated in the following patient groups or clinical scenarios: • • • • • • • • • • Children Acute renal failure Pregnancy Oedematous states Muscle-wasting disease states Amputees Malnourished patients Asian patients Kidney transplants People with diabetes.