By Frank F. Bier, Soeren Schumacher (auth.), Harald Seitz, Sarah Schumacher (eds.)

Integration in Bioanalysis: applied sciences for Point-of-Care checking out, by means of Frank F. Bier, Soeren Schumacher

Future of medication: versions in Predictive Diagnostics and customized medication, through Babette Regierer, Valeria Zazzu, Ralf Sudbrak, Alexander Kühn and Hans Lehrach

A hugely flexible Microscope Imaging expertise Platform for the Multiplex Real-Time Detection of Biomolecules and Autoimmune Antibodies, via Stefan Rödiger, Peter Schierack, Alexander Böhm, Jörg Nitschke, Ingo Berger, Ulrike Frömmel, Carsten Schmidt, Mirko Ruhland, Ingolf Schimke, Dirk Roggenbuck, Werner Lehmann, Christian Schröder

Platform applied sciences for Molecular Diagnostics close to the Patient’s Bedside, through Soeren Schumacher, Christine Lüdecke, Eva Ehrentreich-Förster, Frank F. Bier

Microfluidic know-how for Molecular Diagnostics, through Tom Robinson, Petra S. Dittrich

Biosensors for Diagnostic functions, via Friederike J. Gruhl, Bastian E. Rapp, Kerstin Länge

Planar Protein Arrays in Microtiter Plates: improvement of a brand new layout in the direction of exact, Automation-Friendly and reasonable (A3) Diagnostics, by means of Holger Eickhoff, Arif Malik

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De S. Rödiger Á I. de 36 S. Rödiger et al. small reaction volumes, are presented together with a high-content detection of autoimmune antibodies using a HEp-2 cell assay. Its adaptiveness and versatility gives VideoScan a competitive edge over other bioanalytical technologies. Á Á Keywords Autoimmune diagnostic Hybridization kinetics Immunofluorescence patterns Microbeads Microscope imaging technology Multiplex Real-time Á Á Á Á Contents 1 2 Introduction..........................................................................................................................

The integration of molecular data into these models will allow comprehensive understanding of the mechanisms and the pathophysiology of diseases. 26 B. Regierer et al. 3 Molecular Models Many diseases have molecular causes. Therefore knowledge about the genetic make-up of the human body, the molecular components on all levels along the line of the flow of biological information, as well as their behavior and interrelations, need to be integrated in consistent approaches to understand the underlying mechanisms of diseases.

The aim of the ITFoM project is the creation of the ‘virtual patient’ model integrating all different layers of genomic, physiological, and other relevant information to support health professionals in their decision-making process for therapy and prevention strategies for each individual patient. eu) is a flagship pilot project developing a research programme to achieve truly individualized medicine in 2025. Initiated by a call from the European Future and Emerging Technologies programme, the ITFoM pilot connects the experts in Europe and worldwide to address this challenge and enable data-driven personalized medicine in the future [4, 9, 45].

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