By John D. Ash, Christian Grimm, Joe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail, Catherine Bowes Rickman

Contains the court cases of the XVI overseas Symposium on Retinal Degeneration (RD2014), to be held July 13-18, 2014 on the Asilomar convention heart in Pacific Grove, California. A majority of these who will converse and current posters on the assembly will give a contribution to this quantity. The Symposium addresses the blinding illnesses of inherited retinal degenerations, that have no potent remedies and age-related macular degeneration, which has no therapies, even though it's an endemic one of the aged, with 1 in 3-4 tormented by the age of seventy five. The RD2014 Symposium will specialize in the fascinating new advancements geared toward figuring out those ailments and supplying treatments for them.

The quantity will current consultant state of the art examine in just about all components of retinal degenerations, starting from cytopathologic, physiologic, diagnostic and scientific elements; animal versions; mechanisms of cellphone loss of life; molecular genetics; and constructing power healing measures equivalent to gene remedy and neuroprotective brokers for power pharmaceutical remedy; and several other sight recovery techniques, together with optogenetics. whereas advances in those parts of retinal degenerations may be incorporated, a number of new themes both have been of their infancy or didn't exist on the time of the final RD Symposium, RD2012. those contain many new advancements in sight recovery utilizing optogenetics, retinal or RPE phone transplantation, stem mobilephone techniques and visible prosthetic units. moreover, significant advances should be offered in different uncomplicated mechanisms in age-related macular degeneration, a number of new points of gene and antioxidant remedy and innovative new imaging and sensible trying out that might have a big impact at the analysis and following the process retinal degenerations, in addition to to supply new quantitative endpoints for scientific trials. The retina is an approachable a part of the relevant apprehensive method (CNS), and there's a significant curiosity in neuroprotective and gene treatment for CNS illnesses and neurodegenerations, often. it's going to be famous that with profitable and fascinating preliminary medical trials in neuroprotective and gene treatment, together with the recovery of sight in blind teenagers, the retinal degeneration remedies are prime the best way in the direction of new healing measures for neurodegenerations of the CNS. the various successes lately stated in those parts of retinal degeneration sprang from collaborations tested at prior RD Symposia, and plenty of of these should be suggested on the RD2014 assembly and included.

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Thome Memorial Foundation Award. She has published more than 40 original research and review articles and has edited two books on inherited and environmentally induced retinal degenerations. She currently serves on the Scientific Advisory Boards of the Foundation Fighting Blindness (Owings Mills, Maryland), the Beckman Initiative for Macular Research (Irvine, California) and the Macular Degeneration program of the BrightFocus Foundation (Clarksburg, Maryland) and is a consultant for GlaxoSmithKline and Pfizer.

The last few years has been dedicated towards better understanding the impact of the complement system on the onset and progression of AMD using novel mouse models. Dr. Bowes Rickman’s research program has been continually funded by the NIH since 1995 and she has also received support from Research to Prevent Blindness (RPB) Foundation, the Foundation Fighting Blindness, the Macular Degeneration program of the American Health Assistance Foundation, Macula Vision Research Foundation, and The Ruth and Milton Steinbach Fund.

He also served as President (1988–1991) and Secretary (1984–1987) of the International Society of Eye Research. He is Chairman of the scientific review panel for the Macular Degeneration program of the BrightFocus Foundation (Clarksburg, Maryland), serves on the scientific advisory boards of the Foundation Fighting Blindness (Owings Mills, Maryland), the Helen Keller Eye Research Foundation (Birmingham, Alabama), the South Africa Retinitis Pigmentosa Foundation (Johannesburg, South Africa), is Co-Chairman of the Medical and Scientific Advisory Board of Retina International (Zurich, Switzerland), and is a member of the Board of Trustees of Hendrix College.

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