By Lester Packer
This leading edge reference explores a big variety of issues linked to getting older, delivering an exceptional realizing of the importance and molecular foundation of the getting older procedure and charting the process destiny study within the region.
Stresses the interaction of mitochondria, mitochondrial DNA, oxidants, and antioxidants!
Featuring the examine of over fifty five specialists within the sector, figuring out the method of Aging
Featuring over 1800 references, tables, drawings, and images, figuring out the method of getting older merits nutritionists and dieticians, geriatricians, phone and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and clinical university scholars in those disciplines.
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Additional info for Understanding the Process of Aging: The Roles of Mitochondria: Free Radicals, and Antioxidants
Example text
Mitoc hondrial respiration scavenges eylosolie Ol - that diffuses into the intermembrane space. thereby complementing the Ol- scavenging by Cu,Zn·SOD. Therefore, mitochondria nrc directly involved in Ol - homeostasis throughout the cell. unde rstandi ng of how mitochondrial resp iration influences oxidative stress will he s uhject 10 frequent revision. REFERENCES I. 2. 3. McCord 1M , Keele BB 1r, Fridovich I. An enzyme-based theory of obligatc nnnerobiosis: the physiological function of supcroxidc diSlIlutasc.
Free radical fOr'Jllati or ~ in biological systerllS is thu s arl esserrtial part of normal physiology and a potential route to the pathophysiology associated with a number of diseases. As will be secn, this is wel l exemplified in the mitochondrion through the interactions of free radicals with transition metal centers in the o rganelle. Biochemistry of Nitric Oxide and Peroxynitrlte III. 41 THE ORIGIN OF NO IN BIOLOGICAL SYSTEMS: NO SYNTHASES Since the interaction of NO will be an important aspect o f our discussion we wi ll briefly provide background covering the biochemislrY of the enzymes and NO.
Mitochondrial Production 01 Oxygen Radicals 28. 29. 30. 3 1. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41 . 42. 43. 44. 45. 46. 15 liver homogenates and isolated hcpatocytes upon inhibition of 0 1 - and H 10 1 utilization. Free Radic Bioi Med 1986; 2:135- 140, Lloyd D. Boveri ~ A. Reiter R. Filipkowski M. Chance B. Chemiluminescence of AClInthamoeba castellanN. Bioche m J 1979: 184:149- 156. Kokinuma K. Cadenas E. Boveris A. Chance B. Low level chemiluminescence of intac t polymorphonuclear leukocytes, FEBS Leu 1979; 102:38-42.