By Novartis Foundation
With the ever-increasing upward thrust in lifestyles expectancy, there's an pressing have to enhance our figuring out of the connection among growing old and the pathogenesis of age-related ailments which will establish better technique of prevention, amelioration and administration of such illnesses. moreover, there's a have to decrease the social and fiscal impression of the ageing inhabitants. Age-related morbidity and mortality vary dramatically between contributors; this e-book focusses on person variations in susceptibility to age-related issues.
It comprises contributions from top specialists within the box on issues such as:
age-related pathology within the mind, age-related procedures in stem cells, and age-related results at the immune approach and in bone, muscle and cardiovascular tissue. For all people with an curiosity within the biology of getting old, this is often obligatory reading.Content:
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Additional info for Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235
Sample text
Br J Ophthalmol 82:186^188 Chen YC, Reid GE, Simpson RJ, Truscott RJ 1997 Molecular evidence for the involvement of a-crystallin in the colouration/cross-linking of crystallins in age-related nuclear cataract. Exp Eye Res 65:835^840 Cherny RA, Legg JT, McLean CA et al 1999 Aqueous dissolution of Alzheimer’s disease Ab amyloid deposits by biometal depletion. J Biol Chem 274:23223^23228 Cook CS, McGahan MC 1986 Copper concentration in cornea, iris, normal, and cataractous lenses and intraocular £uids of vertebrates.
But the metals may play more of a role than simply assembling Ab aggregates. Indeed, the electrochemical interaction between the metal and the Ab peptide appears to be of paramount importance in producing toxic e¡ects. This supposition is illustrated by our recent report that Ab itself is redox-active, reduces Cu (II) and Fe (III), and produces H2O2 by electron transfer to molecular oxygen (Huang et al 1999a). The rank order in which Ab species both reduce metal and produce H2O2 is greatest for human Ab1^424 human Ab1^40 ) rodent Ab1^40&0.
Presenilin 1 is the most common mutation responsible for the ¢rst class of gene action. There are perhaps only 140 families in the world with those mutations. They are thus extraordinarily rare. Kalaria: Your data suggest we can do something about AD without arresting amyloid deposition or processing. The inverse plot you presented showed that the compaction of amyloid reduces oxidation. This indicates to me that it is soluble Ab1À42 that is important in terms of creating this oxidative cycle. Can this be tested in an animal model?