By Vincent J. Cristofalo PhD
This quantity offers a transparent, concise evaluation of the present kingdom of information in regards to the biology of getting older ñ serving as either a useful graduate-level textual content and a key reference for working towards pros. Over a dozen distinctive individuals probe the most recent advancements in our wisdom of why humans age and the way the method works. those authoritative chapters are usually not simply written for biologists ñ yet for gerontologists in most cases. Marks the 10th anniversary of the yearly evaluate of Gerontology and Geriatrics.
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Extra resources for Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging
Sample text
A striking feature is progressive intracranial calcification, which can be detected by computed tomographic scan or skull X-ray film. Although the degree of neurological deterioration can be variable, death usually is a result of progressive neurodegeneration during late childhood or early adolescence. , 1977). Growth of cells, as assayed by colony-forming ability following UV irradiation, is much reduced compared to normal. , 1982). No known defect in excision or DNA repair has yet been defined.
Although the degree of neurological deterioration can be variable, death usually is a result of progressive neurodegeneration during late childhood or early adolescence. , 1977). Growth of cells, as assayed by colony-forming ability following UV irradiation, is much reduced compared to normal. , 1982). No known defect in excision or DNA repair has yet been defined. It has been suggested that UV irradiation produces a chromatin alteration that inhibits replicon initiation (Cleaver, 1982). Three complementation groups have been defined based on RNA synthesis following somatic fusion and UV irradiation, which suggests that heterogeneity is present in the syndrome (Lehmann, 1982).
Walford, R. L. (1979). Multigene families, histocompatibility system, transformation, meiosis, stem cells and DNA repair. Mechanisms of Aging and Development, 9, 19. Walford, R. , et al. (1981). Immunopathology of aging. In C. ), Annual Review of Gerontology and Geriatrics (Vol. 2, p. 3). New York: Springer Publishing Co. Wareham, V. , et al. (1987). Age related reactivation of an X-linked gene. Nature, 327, 725. 22 V. J. CRISTOFALO Warthin, A. S. (1929). Old age, the major revolution: The philosophy and pathology of the aging process.