By Dipl.-Phys E. Steiger (auth.), Prof. Dr. K. R. Karsch, Dr. K. K. Haase (eds.)

Since the improvement of the 1st laser generator by way of Maiman in 1960, laser power has won elevated curiosity and has as a result been utilized in numerous fields of applica­ tion. as a result of its excessive power density, mixed with a sharply outlined irradiation box, laser has aroused nice expectancies, specially seeing that laser beams were used very effectively in numerous fields in particular know-how and medication. scientific and surgical functions of the laser have been one of the first and feature been of undisputed gain in, for instance, ophthalmologic interventions akin to coagulation of the retina, or for endoscopic tumorectomy within the bronchial, gastrointestinal and urogenital tracts. as a result, significant study attempt used to be made to additionally observe laser recommendations in interventional cardiology for the remedy of atherosclerosis, aimed toward elimination plaque fabric from stenosed tissue or occluded ateries and recanalizing difficult and calcified segments incorrect for the well-extablished means of balloon dilatation. Ablating atheroma instead of pushing it apart was once notion to accomplish larger effects. despite the fact that, it was once came across that the laser might create rough-edged cuts partially with gigantic thermal or mechanical harm to the encircling tissue, accordingly scary preconditions for undesirable restenosis. varieties of laser turbines and probes have accordingly been investigated in arterial vessels, ordinarily concentrating on oblique laser results. Intravasal probes with laser­ heated steel advice have been used, in addition to balloon catheters with an included laser fiber designed to warmth the encompassing tissue outdoor the balloon and to, ineffect, "iron out the plaque".

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The angioplasty catheter was inflated two times with 5 atm for 30 s. Between the two dilatations the balloon was deflated for 30 s. After removal of the deflated catheter, the small incision of the arteriotomy was closed and arterial blood flow restored. To avoid bacterial infections, all animals were on antibiotic therapy for 3 days following the procedure. Standard heparin was not administered during or after intervention. After balloon angioplasty a commercially available standard diet without cholesterol (Fa.

JACC 16: 1665-1671 41 24. Callow AD (1990) What's new in surgery: Peripheral vascular surgery. ACS bulletin 75: 49-51 25. Chervu A (1990) Myo-intimal hyperplasia. Seminars in vascular surgery 3: 21-28 26. Yashima Y, McAuliffe OJ, Jacques SL, FIotte TJ (1991) Laser-induced photoacoustic injury of skin: Effect of inertial confinement. Laser Surg Med 11: 62-68 Authors' address: R. Srinivasan, Ph. D. UVTech Associates 2508 Dunning Drive Yorktown Heights New York 10598 USA 42 Mid-infrared Laser Coronary Angioplasty Experimental Study H.

3). Focal intimal dissection or medial disrupture was not found in these segments. In five other animals a complete thrombotic occlusion was found. The mural thrombi observed after angioplasty showed evidence of fibromuscular organization and all ofthese thrombi were partially recanalized. Medial disrupture was seen in two other animals and both were associated with mural thrombi reducing the luminal diameter by less than 50%. In four dilated arteries a focal splitting of the intima with shearing off of the endothelial layer was observed.

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