By Michael Strong, Andrew Kertesz

Dementia and Motor Neuron illness is a unmarried authoritative reference at the present figuring out of frontotemporal dementia in amyotrophic lateral sclerosis (ALS). This complete paintings is perfect for scientific and examine teams targeting dementia or ALS, in addition to these operating within the fields of neuroimaging and neuropsychology.

Key subject matters lined include:
• Frontotemporal dementia, together with historical past, anatomy and impairment
• medical phenomenology and treatment
• Neuropathological, cognitive disorder and changed cognition spectrums
• Neuroimaging
• Molecular and mobile neuropathology
• Genetics
• Neurochemistry

With contributions from foreign opinion leaders in dementia and motor neuron illness, this can be a exceptional reference for proven clinicians and researchers, in addition to graduate scholars learning neurodegeneration.

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Extra resources for Dementia and Motor Neuron Disease

Sample text

78. 79. 80. 81. 82. (Arg5His) tau gene mutation. Ann Neurol 2002; 51:525–30. Hong M, Zhukareva V, Vogelsberg-Ragaglia V, et al. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 1998; 282:1914–17. Nacharaju P, Lewis J, Easson C, et al. Accelerated filament formation from tau protein with specific FTDP17 missense mutations. FEBS Lett 1999; 447:195–9. D’Souza I, Poorkaj P, Hong M, et al. Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements.

Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998; 51:1546–54. 7. Kertesz A, Munoz DG, Hillis A. Preferred terminology. Ann Neurol 2003; 54:S3–S6. 8. Hodges JR, Miller B. The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers: Part I. Neurocase 2001; 7:31–5. 03-chap03-cpp 13/6/06 1:11 pm Page 29 CLINICAL PHENOMENOLOGY AND TREATMENT OF FRONTOTEMPORAL DEMENTIA 29 9.

1 The clinical diagnostic features of FTD: clinical profile I. Core diagnostic features A. Insidious onset and gradual progression B. Early decline in social interpersonal conduct C. Early impairment in regulation of personal conduct D. Early emotional blunting E. Early loss of insight II. Supportive diagnostic features A. Behavioral disorder 1. Decline in personal hygiene and grooming 2. Mental rigidity and inflexibility 3. Distractibility and impersistence 4. Hyperorality and dietary changes 5.

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