By Edward L. Schneider and John W. Rowe (Eds.)

Meant for researchers and graduate scholars within the biology of growing old, this e-book presents a basic evaluation of biomedical gerontology and an replace to prior versions. It makes a speciality of 3 significant assets of impression on growing old: organic, mental and social

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1. The protozoa have shown the importance of DNA and RNA processing in the regulation of developmental events. The discovery that RNA functions as an enzyme, the ribozyme, opens a new research arena to discover how splicing of RNA can affect cell viability and longevity. Aging in fungi is believed to be due to alteration of DNA or RNA processing. 2. DNA processing mutants in ciliates provided a molecular basis for cytoplasmic control of gene expression. Thus, cells with the same genotype can express different phenotypes in response to the cytoplasmic directives.

Amicro­ nucleate strains exist naturally and can be generated in the laboratory with great dif­ ficulty using mutagenesis in Tetrahymena and laser surgery in Paramecium and Stylonychia. It is not clear how the immortal amicronucleates arose in Tetrahymena (Nanney, 1974). The fact that amicronucleate strains are viable cannot be considered evidence that the micronuclei have no function (Ammermann, 1988) since it was demonstrated that ami­ cronucleate Tetrahymena contain DNA sequences in the macronucleus which are normally present in the micronucleus (Karrer, Stein-Gavens, & Allitto, 1984; SteinGavens, Wells, &Karrer, 1987).

1984a). Analysis of germinal aging in Paramecium caudatum by micronuclear transplantation. Experimental Cell Research, 136, 407-415. , &Hiwatashi, K. (1984b). Resistance of germinal nucleus to aging in Paramecium : Evidence obtained by micronuclear trans­ plantation. Mechanisms of Aging and Development, 26, 51-66. Karrer, K. (1986). The nuclear DNA of holotrichous ciliates. In J. G. ), The molecular biology of ciliated protozoa (pp. 8 5 110). Orlando, FL: Academic Press. , 8k Allitto, B. A. (1984).

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