By D. Greene, S. K. Stephenson (auth.), Eric C. Easson CBE, MSc, MD, FRCP, FRCR, R. C. S. Pointon MA, FRCP, FRCR (eds.)
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Extra resources for The Radiotherapy of Malignant Disease
2) Whenever possible, the trial results should lead to a more precise definition of the "optimum dose" for a given situation. There is a fundamental difference in the aims of therapeutic radiation in normal and malignant tissues. In the former case, the intention is to deliver to the normal tissue a dose of ionising radiation which will deplete the number of those cells capable of regenerating that tissue (clonogenic cells, see below) to levels at or above that necessary for continued function of the tissue, and which will be consistent with the long-term integrity of its associated stroma and vasculature.
2) Tables or graphs of numerical data from which dosimetry calculations for every arrangement of sources prescribed by the distribution rules can be quickly performed without the need for more than simple arithmetic. These data were originally expressed as the total number of milligram-hours of radium required to deliver a "uniform" exposure of 1000 rontgens. More recently, the data have been converted to the form "radium milligram-hours per 1000 centigrays" and will be employed in this form in this book.
The wedge filters should be orientated as shown, with the thick end of each wedge reducing the dose at the A side of the field. Further, to achieve equal doses at A and B, thus avoiding undesirable dose gradients across the tumour, the isodose lines from each field should run parallel to the line AB. In principle, then, this treatment can be planned by having a family of wedged isodose charts, and selecting the one which has isodose lines parallel to AB when placed with its central axis along either of the lines 5 10 or 52 0.